NERLYNX® (neratinib) is a once-daily oral medicine for women who have just finished trastuzumab therapy (i.e., Herceptin®) following surgery for early-stage breast cancer.

NERLYNX is the first HER2-targeted treatment approved by the FDA to further reduce the risk of recurrence after Herceptin. Talk with your healthcare team to decide if the treatment is right for you.

Take the next step with NERLYNX

NERLYNX can help support everything you’ve already done to treat your breast cancer:

before surgery (if indicated) neoadjuvant therapy


treatment after surgery (chemotherapy and Herceptin® [trastuzumab]) adjuvant therapy

nerlynx, an anti-her2
targeted therapy extended adjuvant therapy

NERLYNX: A different kind of treatment

NERLYNX is an oral, extended adjuvant therapy, meaning it is designed to be taken after your adjuvant Herceptin treatment (following surgery). NERLYNX targets HER2+ breast cancer in a different way by working inside the cell to block the pathways that can lead to tumor growth.

How NERLYNX may help

Normally, HER2 receptors on healthy cells send signals to tell the cells when to grow. In HER2+ breast cancer, some cancer cells have too many HER2 receptors. These cells grow and divide uncontrollably.

Other HER2 treatments may work by interfering with HER2 receptors from outside the cell. NERLYNX interacts with multiple HER family receptors inside the cell to block multiple growth pathways. This alters the signals that lead to cancer growth.

Nerlynx Mentor Program

Connect with women who know what it's like to experience NERLYNX. If you are considering treatment with NERLYNX and have questions about what to expect, speak with a mentor.

Learn more


You can have NERLYNX information and tips sent to your phone for free by texting LYNX to 90803 or enter your number below.

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At no cost with an unlimited texting plan; otherwise, message & data rates may apply. Message frequency determined by user. Text HELP to 90803 for help. Text STOP to 90803 to cancel. Click here for Terms & Conditions.


Download a NERLYNX brochure

Your resource to help you get started on treatment with NERLYNX.



Talk openly with your doctor or nurse. It’s okay to speak up and say you don’t understand something. Ask the questions you may even feel uncomfortable bringing up. You and your healthcare team are partners when it comes to your health. That means communication is key.

What to ask to get the information you need

  • I want to make sure I take NERLYNX correctly. How should I take it?
  • What side effects should I expect and how do I manage the common ones?
  • How can I minimize any diarrhea I may experience?
  • What should I do if a side effect worsens or starts to concern me?

Always keep your healthcare team in the loop with how you’re feeling and what you’re thinking. Tell your team what’s going on, the conversation doesn’t have to just be questions.

Things like writing down and sharing any side effects you experience or anything that’s bothering you can be great topics of conversation.

Download frequently asked questions

See a list of commonly asked questions and answers about NERLYNX.

Explore our patient support
program and services

*Recurrence is defined as an invasive disease event or death.


What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. You may lose too much body salts and fluids, and get dehydrated. Your healthcare provider should prescribe the medicine loperamide for you during your first 2 months (56 days) of NERLYNX and then as needed.

Please see additional IMPORTANT SAFETY INFORMATION below.


What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.