About recurrence

Trastuzumab has improved but not eliminated the risk of recurrence in early-stage HER2+ breast cancer5-8


of patients with early-stage HER2+ breast cancer experience a disease-free survival event within 10 years as observed in the HERA trial.8

HERA trial long-term disease-free survival* (DFS) outcomes

5 6 7 8
  • Recurrent HER2+ breast cancer is mostly incurable6

  • Once distant recurrence has occurred, the disease remains largely incurable, and patient survival is low6,7

  • Longer duration of adjuvant therapy with current agents has not been shown to lower the recurrence risk8

  • HER2+ patients remain at risk for disease recurrence after adjuvant trastuzumab8

Extended adjuvant therapy can further reduce the risk of recurrence of early-stage HER2+ breast cancer.1

HER2: human epidermal growth factor receptor 2

*Disease-free survival, defined as time from randomization to the first occurrence of any of the following disease-free survival events: recurrence of breast cancer at any site; the development of ipsilateral or contralateral breast cancer, including ductal carcinoma in situ but not lobular carcinoma in situ; second nonbreast malignant disease other than basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix; or death from any cause without documentation of a cancer-related event.5

Learn how NERLYNX works


NERLYNX® (neratinib) tablets, for oral use

INDICATIONS AND USAGE: NERLYNX is a kinase inhibitor indicated for the extended adjuvant treatment of adult patients with early-stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy.



ADVERSE REACTIONS: The most common adverse reactions (>5%) were diarrhea, nausea, abdominal pain, fatigue, vomiting, rash, stomatitis, decreased appetite, muscle spasms, dyspepsia, AST or ALT increase, nail disorder, dry skin, abdominal distention, weight decreased and urinary tract infection.

To report SUSPECTED ADVERSE REACTIONS, contact Puma Biotechnology, Inc. at 1-844-NERLYNX (1-844-637-5969) and www.NERLYNX.com or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.



For Full Prescribing Information, please click here.