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Access and support
Access and Support

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Support for patients prescribed NERLYNX
Enrollment Form
Spanish/Español
NERLYNX Co-pay Card
ACCESS AND REIMBURSEMENT

  • Benefits Verification and Prior Authorization Assistance

    Our Nurse Case Manager will conduct a benefits investigation, verify insurance approval or coverage, and obtain and submit necessary documentation for patients requiring prior authorization.

  • NERLYNX Quick Start

    Puma Biotechnology provides a free 3-week supply of NERLYNX to eligible patients experiencing delays in gaining access to therapy.

  • Co-Pay Assistance

    Puma Biotechnology offers co-pay assistance to help qualified insured patients with the out-of-pocket costs associated with their NERLYNX prescription.

  • Financial Support

    For patients with financial needs, we will work to find appropriate sources for support.

ONGOING TREATMENT SUPPORT

  • NERLYNX Mentor Program

    This program is available to all patients with HER2+ breast cancer who are considering or currently taking NERLYNX.

  • Nurse Support

    Our nurses are available to speak with patients and healthcare providers to answer questions about NERLYNX. The call center is open Monday through Friday, 9 AM - 8 PM EST.

  • Product Support

    Our specialty pharmacy network will provide patients with product education and side-effect counseling to help them better understand and manage their NERLYNX therapy.

  • Text Message Support

    Patients can sign up to receive medication reminders and motivational messages to support treatment adherence.

Supportive Care Voucher Program

  • Up to 3 months’ free supply per antidiarrheal product

  • Available to all patients

  • Used at the dispensing pharmacy, with prescription(s) at local retail pharmacy, or through Puma Specialty Pharmacy network

For more information on the Puma Patient Lynx Support Program, call 1-855-816-5421.
How to get NERLYNX
NERLYNX is available through specific specialty pharmacies. To learn about reimbursement, download the form below.
Enrollment Form
Spanish/Español
Sample Letter of Medical Necessity
  • AcariaHealth™
    T: (800) 511-5144 F: (877) 541-1503
    Hours of operation:
    M-F, 8 am–10 pm (ET)
  • Biologics, Inc.
    T: (800) 850-4306 F: (800) 823-4506
    www.biologicsinc.com
    Hours of operation:
    M-F, 8 am–8 pm (ET)
  • Diplomat Specialty Pharmacy
    T: (877) 977-9118 F: (800) 550-6272
    Hours of operation:
    M-F, 9 am–9 pm (ET); Sat., 9 am–5 pm (ET)
  • Accredo® Health Group, Inc.
    T: (877) 732-3431 F: (866) 352-3973
    Hours of operation:
    M-F, 8 am–11 pm (ET)
  • CVS Caremark Specialty Pharmacy
    T: (844) 239-4761 F: (855) 296-0210
    Hours of operation:
    M-F, 8:30 am–8:30 pm (ET)
  • Onco360®
    T: (877) 662-6633 F: (877) 662-6355
    Hours of operation:
    M-F, 8 am–7 pm (ET); Sat., 9 am–2 pm (ET)

National Drug Code (NDC)

NERLYNX 40 mg film-coated tablets
Package Size: 180 tablets
NDC: 70437-240-18

The NERLYNX patient co-pay card is available
Puma Biotechnology offers co-pay assistance to help qualified insured patients with the out-of-pocket costs associated with their NERLYNX prescription.
NERLYNX Co-pay Card
Commercially insured, eligible patients treated with NERLYNX may pay as little as $10 per prescription.* Patients will be enrolled through their specialty pharmacy. To verify your patients' eligibility or to enroll them in the co-pay card program, visit this website or call Puma Patient Lynx at 1-855-816-5421.
*Limitations apply. Patient must have commercial insurance. Offer is not valid under Medicare, Medicaid, or any other federal or state program. Puma Biotechnology reserves the right to rescind, revoke, or amend this program without notice. For full terms and conditions, call 1-855-816-5421.

IMPORTANT SAFETY INFORMATION

NERLYNX® (neratinib) tablets, for oral use

INDICATIONS AND USAGE: NERLYNX is a kinase inhibitor indicated:

CONTRAINDICATIONS: None

WARNINGS AND PRECAUTIONS:

ADVERSE REACTIONS: The most common adverse reactions (reported in ≥5% of patients) were:

To report SUSPECTED ADVERSE REACTIONS, contact Puma Biotechnology, Inc. at 1-844-NERLYNX (1-844-637-5969) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS:

USE IN SPECIFIC POPULATIONS:

For Full Prescribing Information, please click here.

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Reference:

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  2. Martin M, Holmes FA, Ejlertsen B, et al. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017;18(12):1688-1700.
  3. NERLYNX (neratinib) tablets Prescribing Information, Puma Biotechnology, Inc. 04/20.
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  9. Pierce JP, Patterson RE, Senger CM, et al. Lifetime cigarette smoking and breast cancer prognosis in the After Breast Cancer Pooling Project. J Natl Cancer Inst. 2014;106(1):djt359.
  10. Esserman LJ, Berry DA, DeMichele A, et al. Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 trial—CALGB 150007/150012, ACRIN 6657. J Clin Oncol. 2012;30(26):3242-3249.
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  13. Von Minckwitz G, Huang C-S, Mano MS, et al. Trastuzumab emtansine for residual invasive HER2-positive breast cancer. N Engl J Med. 2019;380(7):617-628.
  14. Singh JC, Jhaveri K, Esteva FJ. HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug development. Br J Cancer. 2014;111(10):1888-1898.
  15. Brufsky AM, Mayer M, Rugo HS, et al. Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER. Clin Cancer Res. 2011;17(14):4834-4843.
  16. Untch M, Geyer CE Jr, Huang C-S, et al. Peripheral neuropathy (PN), thrombocytopenia (TCP) and central nervous system (CNS) recurrence: an update of the phase III KATHERINE trial of post-neoadjuvant trastuzumab emtansine (T-DM1) or trastuzumab (H) in patients (pts) with residual invasive HER2-positive breast cancer (BC). Slides presented at: 2019 European Society for Medical Oncology (ESMO) Annual Meeting; September 30, 2019; Barcelona, Spain.
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  22. Puma Biotechnology, Inc. Data on file. 02/20.
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  24. Puma Biotechnology. FDA ODAC Sponsor Presentation. May 24, 2017.
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  34. Zhao XQ, Xie JD, Chen XG, et al. Neratinib reverses ATP-binding cassette B1-mediated chemotherapeutic drug resistance in vitro, in vivo, and ex vivo. Mol Pharmacol. 2012;82(1):47-58.
  35. Collins DM, Conlon NT, Kannan S, et al. Preclinical characteristics of the irreversible pan-HER kinase inhibitor neratinib compared with lapatinib: implications for the treatment of HER2-positive and HER2-mutated breast cancer. Cancers (Basel). 2019;11(6):E737.
  36. Prat A, Baselga J. The role of hormonal therapy in the management of hormonal-receptor-positive breast cancer with co-expression of HER2. Nat Clin Pract Oncol. 2008;5(9):531-542.
  37. Pohlmann PR, Mayer IA, Mernaugh R. Resistance to trastuzumab in breast cancer. Clin Cancer Res. 2009;15(24):7479-7491.
  38. Giuliano M, Trivedi MV, Schiff R. Bidirectional crosstalk between the estrogen receptor and human epidermal growth factor receptor 2 signaling pathways in breast cancer: molecular basis and clinical implication. Breast Care. 2013;8:256-262.
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  40. Paplomata E, Nahta R, O'Regan RM. Systemic therapy for early-stage HER2-positive breast cancers: time for a less-is-more approach? Cancer. 2015;121(4):517-526.
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