Diarrhea and antidiarrheal prophylaxis1
Prophylaxis with loperamide has been shown to lower the incidence and severity of diarrhea
Start loperamide with the first dose of NERLYNX and continue during the first two cycles (56 days) of treatment. Continue loperamide as shown below, titrating to 1-2 bowel movements per day
Loperamide prophylaxis guidance1
Additional antidiarrheal agents may be required to manage diarrhea in patients with loperamide-refractory diarrhea
NERLYNX dose interruptions and dose reductions may also be required (please see Full Prescribing Information)
Please see additional guidelines for the management of adverse events, including hepatotoxicity, in the Full Prescribing Information
Voucher program for a 3-month supply of antidiarrheals is available to eligible patients
In order to best support the patient's experience on NERLYNX, our service program has been expanded to include coverage of products used for antidiarrheal treatment, as based on findings from CONTROL.
This support can be accessed by your patient through a voucher, which can be obtained from your Puma sales representative or from one of the Puma network specialty pharmacies. The voucher can be used at any retail pharmacy to provide your patient a FREE 3-month supply of product(s) that you prescribe for antidiarrheal treatment.
Qualifying guidelines and additional utilization instructions are provided in the voucher.
Select IMPORTANT SAFETY INFORMATION
Embryo-Fetal Toxicity: NERLYNX can cause fetal harm. Advise patients of potential risk to a fetus and to use effective contraception.
Lactation: Advise women not to breastfeed.
Please see additional IMPORTANT SAFETY INFORMATION below.