Just 1 risk factor further increases risk of recurrence4-9
RISK CONSIDERATIONS IN HER2+ EARLY BREAST CANCER PATIENTS
1 or more positive nodes4
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At 10 years, 25% of patients with 1–3 positive nodes experienced recurrence
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At 10 years, 45% of patients with ≥4 positive nodes experienced recurrence
Tumor size ≥2 cm5
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Tumors 2 cm to 5 cm in greatest dimension were associated with a 53% increase in the risk of recurrence*
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Tumors >5 cm in diameter were associated with an 81% increase in the risk of recurrence*
Lack of pCR6
Not achieving a pCR puts patients at greater risk: achieving a pCR reduced the risk of recurrence by 74% at 3 years compared with no pCR
Patients with HER2+ HR+ breast cancer may be less likely to achieve a pCR than patients with HER2+ HR- breast cancer
Other risk factors include: