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NOW APPROVED for early-stage HER2+ breast cancer

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NERLYNX (neratinib) is a once-daily oral medicine for women who have just finished trastuzumab therapy (ie, Herceptin®) following surgery for early-stage breast cancer. NERLYNX works inside the cell to block the pathways that drive HER2+ breast cancer.

NERLYNX is FDA approved. Now you can talk with your healthcare team to decide if the treatment is right for you.

See what questions to ask

NERLYNX: A different kind of treatment

NERLYNX is an oral, extended adjuvant therapy, meaning it is designed to be taken after your adjuvant Herceptin treatment (following surgery). NERLYNX is the first HER-2 targeted treatment approved by the FDA to further reduce the risk of recurrence after Herceptin.

Normally, HER2 receptors on healthy cells send signals to tell them when to grow. In HER2+ breast cancer, some cancer cells have too many HER2 receptors. These cells grow and divide uncontrollably.

Other HER2 treatments may work by interfering with the HER2 receptor from outside the cell. NERLYNX interacts with multiple HER family receptors and works inside the cell to block multiple growth pathways. This alters the signals that lead to cancer growth.

The most common side effect of NERLYNX is diarrhea. See below for more information.

* Recurrence is defined as an invasive disease event or death.

Select IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

NERLYNX™ (neratinib) may cause serious side effects including:

Please see additional IMPORTANT SAFETY INFORMATION below.

Learn what to expect while taking NERLYNX

TALK WITH YOUR HEALTHCARE TEAM

Learn what to ask about NERLYNX to get the information you need.

see questions

DOWNLOAD A NERLYNX BROCHURE

Your resource to help you get started on treatment with NERLYNX.

Download brochure

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

NERLYNX (neratinib) may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. You may lose too much body salts and fluids, and get dehydrated. Your healthcare provider should prescribe the medicine loperamide for you during your first 2 months (56 days) of NERLYNX and then as needed. To help prevent or reduce diarrhea:

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs, and H-2 receptor antagonists. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.