Understanding the risk of recurrence

Herceptin® (trastuzumab) has improved outcomes for early-stage HER2+ breast cancer patients, but it has not eliminated the risk of recurrence. Up to one in four early-stage HER2+ breast cancer patients experience recurrence after treatment in the adjuvant setting (after surgery) with Herceptin.

HER2+ breast cancer is an aggressive disease, even when diagnosed and treated early. Compared to some other types of cancers, HER2+ breast cancer has been shown to progress and spread more quickly.

If your breast cancer returns, it usually means it has progressed to metastatic disease (cancer spreading to other parts of the body), making it more difficult to treat. This is why addressing the risk of recurrence is such an important component of your treatment plan.

TAKE THE NEXT STEP IN THE COURSE OF TREATMENT

With NERLYNX, you can feel confident that you’re doing everything possible to reduce the risk of your breast cancer coming back. NERLYNX is an oral, extended adjuvant therapy, meaning it is designed to be taken after your adjuvant Herceptin treatment (following surgery). NERLYNX is the first HER-2 targeted treatment approved by the FDA to further reduce the risk of recurrence after Herceptin.

NERLYNX is proven to further reduce the risk of recurrence

The ExteNET trial evaluated treatment with NERLYNX after adjuvant trastuzumab-based therapy in 1,420 women with early-stage HER2+ breast cancer. In this study, NERLYNX reduced the risk of recurrence* by 34% vs placebo at 2 years.

*Recurrence is defined as an invasive disease event or death.

Learn how nerlynx may help

NAVIGATE YOUR COURSE OF TREATMENT

Think about everything you’ve already done to treat your breast cancer:

treatment
before surgery (if indicated) neoadjuvant therapy

surgery

treatment after surgery (chemotherapy and Herceptin® [trastuzumab]) adjuvant therapy

nerlynx, an anti-her2
targeted therapy extended adjuvant therapy

Download frequently asked questions

To learn more about NERLYNX, see a list of commonly asked questions and answers.

FAQS SPANISH/ESPAÑOL

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OUR PATIENT SUPPORT PROGRAM

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Select IMPORTANT SAFETY INFORMATION

  • Tell your healthcare provider if you have more than 2 bowel movements in 1 day, or you have diarrhea that does not go away.
  • Call your healthcare provider right away, as instructed, if you have severe diarrhea or if you have diarrhea along with weakness, dizziness, or fever.

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

Please see additional IMPORTANT SAFETY INFORMATION below.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs, and H-2 receptor antagonists. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.