Even when diagnosed and treated early, HER2+ breast cancer is an aggressive disease that spreads more quickly than other cancers. If your breast cancer returns, it usually means it has progressed to metastatic disease (cancer spreading to other parts of the body), making it more difficult to treat.

Up to one in four early-stage HER2+ breast cancer patients experience recurrence after post-surgery treatment with Herceptin® (trastuzumab). This means that despite improved outcomes from Herceptin, recurrence can still happen.

Being actively involved in the development of your treatment plan can help you feel more confident in the management of your cancer.


Typical course of therapy Typical course of therapy


NERLYNX is intended for people who have already completed a course of trastuzumab-based therapy (for example, Herceptin) after surgery and chemotherapy.

It takes 1 year to complete a full course of treatment with NERLYNX. With NERLYNX, you can do more to further reduce the risk that your breast cancer will return.

Download frequently asked questions

To learn more about NERLYNX, see a list of commonly asked questions and answers.


Ask your healthcare team whether oral, once-daily NERLYNX should be part of your treatment plan.

Learn how Nerlynx may help


What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.