NERLYNX is the next step in your treatment after trastuzumab-based therapy (i.e., Herceptin®) following surgery, and it works to help reduce the risk of your HER2+ breast cancer returning. So by committing to NERLYNX, you know you're doing everything you can to reduce the risk of your early-stage HER2+ breast cancer from recurring.

Because NERLYNX is an oral medication taken once a day, you have the freedom to take it from anywhere.


You may experience certain side effects when starting and taking NERLYNX.

Diarrhea is one of the most common and early side effects, and there is medicine available to help with this side effect. It is recommended that you start loperamide (Imodium®) with the first dose of NERLYNX and continue it during the first two months of NERLYNX treatment to help proactively minimize any diarrhea you may experience. Your doctor will tell you the best way to take this medication, as well as other ways to manage diarrhea and other side effects.

Nerlynx Mentor Program

Connect with women who know what it's like to experience NERLYNX. If you are considering treatment with NERLYNX and have questions about what to expect, speak with a mentor.

Learn more

Supportive care voucher

In order to best support your experience on NERLYNX, we offer coverage of products used for antidiarrheal treatment.*

This support can be accessed through a voucher, which can be obtained from your healthcare team or from one of the Puma network Specialty Pharmacies. The voucher can be used at any retail pharmacy to provide you up to 3 months FREE supply of product(s) that have been prescribed to you for antidiarrheal treatment.

Please see the voucher for qualifying guidelines and additional utilization instructions.

*This program benefit is offered based on the findings from the CONTROL trial, which show that using antidiarrheals can help to manage diarrhea that may be caused by NERLYNX.


The following tips may help you minimize diarrhea, but always talk to your doctor or nurse first before making any changes to your diet.

foods to eat and avoid

Foods that are low in fiber

e.g., bananas, white rice, applesauce, white bread

Visit and search BRAT diet to learn more

Foods that are high in protein

e.g., beef, skinless chicken,
turkey, eggs

Foods that are high in potassium

e.g., bananas, skinless potatoes, avocados, asparagus tips


Yogurt contains "good" bacteria known as probiotics, which can shorten the duration of diarrhea

Other dairy products

e.g., milk, cheese, ice cream

Alcohol, caffeinated drinks, and sugary sodas

e.g., beer, wine, coffee, soda

Greasy, fatty, and spicy foods

e.g., fried chicken, pizza, peppers

Foods that are high in fiber

e.g., popcorn, pickles, whole grain bread, brown rice

Foods that cause intestinal gas

e.g., broccoli, cabbage, beans, cauliflower

Grapefruit and grapefruit products



  • Eat smaller, more frequent meals
  • Drink 8 to 10 large glasses of clear liquids every day to help prevent dehydration

Learn how to manage side effects with NERLYNX

Download our brochure to help you stay on the road to risk reduction.



Make sure you work closely with your healthcare team to help minimize diarrhea. Keep a record of how often you experience diarrhea along with any other symptoms. Share this record with your doctor or nurse early and often to better manage your side effects.

Aside from over-the-counter medicines like loperamide (Imodium), your healthcare team can provide other ways to help you control your diarrhea, including medications and dietary recommendations.


Get side-effect management tips and additional support sent to your phone for free by texting LYNX to 82866 or enter your number below.

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To find out more about our text support program,
watch this video.


Common side effects

In the clinical study, most of the 1,408 participants who took NERLYNX experienced diarrhea. In addition to diarrhea, other side effects commonly experienced included:

  • nausea
  • stomach-area (abdomen) pain
  • tiredness
  • vomiting
  • rash
  • dry or inflamed mouth, or mouth sores
  • decreased appetite
  • muscle spasms
  • upset stomach
  • nail problems including color change
  • dry skin
  • swelling of your stomach-area
  • weight loss
  • urinary tract infection

There are ways to manage the potential side effects of NERLYNX, so don’t feel discouraged. Talk to your doctor or nurse about how to manage side effects. Your doctor can prescribe medication, recommend over-the-counter medicines, or reduce your dose of NERLYNX to help.

Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.


Call your healthcare provider right away if you get any of the following signs or symptoms of liver problems:

  • tiredness
  • nausea
  • vomiting
  • pain in the right upper stomach-area (abdomen)
  • fever
  • rash
  • itching
  • yellowing of your skin or whites of your eyes

Please see additional IMPORTANT SAFETY INFORMATION below.

how to take NERLYNX

At no cost with an unlimited texting plan; otherwise, message & data rates may apply. Message frequency determined by user. Text HELP to 82866 for help. Text STOP to 82866 to cancel.
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What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.