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NERLYNX is the next step in your treatment after trastuzumab-based therapy (i.e., Herceptin®) following surgery, and it works to help reduce the risk of your HER2+ breast cancer returning. So by committing to NERLYNX, you know you're doing everything you can to reduce the risk of your early-stage HER2+ breast cancer from recurring.
Because NERLYNX is an oral medication taken once a day, you have the freedom to take it from anywhere.
You may experience certain side effects when starting and taking NERLYNX.
Diarrhea is one of the most common and early side effects, and there is medicine available to help with this side effect. It is recommended that you start loperamide (Imodium®) with the first dose of NERLYNX and continue it during the first two months of NERLYNX treatment to help proactively minimize any diarrhea you may experience. Your doctor will tell you the best way to take this medication, as well as other ways to manage diarrhea and other side effects.
Supportive care voucher
In order to best support your experience on NERLYNX, we offer coverage of products used for antidiarrheal treatment.†
This support can be accessed through a voucher, which can be obtained from your healthcare team or from one of the Puma network Specialty Pharmacies. The voucher can be used at any retail pharmacy to provide you up to 3 months FREE supply of product(s) that have been prescribed to you for antidiarrheal treatment.
Please see the voucher for qualifying guidelines and additional utilization instructions.
†This program benefit is offered based on the findings from the CONTROL trial, which show that using antidiarrheals can help to manage diarrhea that may be caused by NERLYNX.
The following tips may help you minimize diarrhea, but always talk to your doctor or nurse first before making any changes to your diet.
Foods that are low in fiber
e.g., bananas, white rice, applesauce, white bread
Visit familydoctor.org and search BRAT diet to learn more
Foods that are high in protein
e.g., beef, skinless chicken,
Foods that are high in potassium
e.g., bananas, skinless potatoes, avocados, asparagus tips
Yogurt contains "good" bacteria known as probiotics, which can shorten the duration of diarrhea
Other dairy products
e.g., milk, cheese, ice cream
Alcohol, caffeinated drinks, and sugary sodas
e.g., beer, wine, coffee, soda
Greasy, fatty, and spicy foods
e.g., fried chicken, pizza, peppers
Foods that are high in fiber
e.g., popcorn, pickles, whole grain bread, brown rice
Foods that cause intestinal gas
e.g., broccoli, cabbage, beans, cauliflower
Grapefruit and grapefruit products
Learn how to manage side effects with NERLYNX
Download our brochure to help you stay on the road to risk reduction.Brochure SPANISH/ESPAÑOL
Make sure you work closely with your healthcare team to help minimize diarrhea. Keep a record of how often you experience diarrhea along with any other symptoms. Share this record with your doctor or nurse early and often to better manage your side effects.
Aside from over-the-counter medicines like loperamide (Imodium), your healthcare team can provide other ways to help you control your diarrhea, including medications and dietary recommendations.
In the clinical study, most of the 1,400 participants who took NERLYNX experienced diarrhea. In addition to diarrhea, other side effects commonly experienced included:
There are ways to manage the potential side effects of NERLYNX, so don’t feel discouraged. Talk to your doctor or nurse about how to manage side effects. Your doctor can prescribe medication, recommend over-the-counter medicines, or reduce your dose of NERLYNX to help.
Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088.
Select IMPORTANT SAFETY INFORMATION
Call your healthcare provider right away if you get any of the following signs or symptoms of liver problems:
Please see additional IMPORTANT SAFETY INFORMATION below.how to take NERLYNX
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about NERLYNX (ner links)?
NERLYNX® (neratinib) may cause serious side effects, including:
Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.
See "What are the possible side effects of NERLYNX?" for more information about side effects.
What is NERLYNX?
NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:
It is not known if NERLYNX is safe and effective in children.
Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs, and H-2 receptor antagonists. You should avoid taking these medicines during treatment with NERLYNX.
What are the possible side effects of NERLYNX?
NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"
Common side effects of NERLYNX include:
These are not all the possible side effects of NERLYNX.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
For Patient Information, please click here.