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  • Take 6 pills once a day (a total of 240 mg) with food for 12 months

  • Avoid grapefruit and grapefruit products

  • Take NERLYNX around the same time every day

  • Do not chew, crush or split tablets

  • Never take more than one dose (6 pills) per day. If you miss a dose, continue with your next scheduled dose on the following day

  • Be sure to let your healthcare provider know about any missed doses during appointments

  • Your provider may recommend that you take an antidiarrheal medication such as loperamide (Imodium®) when you first start NERLYNX. Your provider will decide what dose you should take

Ask your doctor if there are any foods or medicines you should avoid while taking NERLYNX.

Important Instructions

  • Store NERLYNX at room temperature between 68° and 77°F (20° and 25°C)

  • Notify your healthcare provider immediately if you take more than 6 pills at once

Make NERLYNX a part of your daily routine

Think about and plan for a mealtime that works best for taking NERLYNX.

*At no cost with an unlimited texting plan; otherwise, message & data rates may apply. Message frequency determined by user. Text HELP to 90803 for help. Text STOP to 90803 to cancel. Click here for Terms & Conditions.

Getting the most out of NERLYNX

NERLYNX can only do its job if you commit to taking it every day. And during this time of physical and emotional readjustment, managing any stress you may experience is important to staying committed to NERLYNX.

Managing stress during treatment

Some women feel pressure to pick back up the responsibilities they had before their cancer diagnosis. Others feel a drop in the kind of support they experienced from their healthcare provider and friends that comes with fighting cancer.

Whatever you're feeling, if you can take time to understand and accept how you feel in the present moment—without judgment of those feelings—you can learn to better manage stress and anxiety.

Deep breathing is a proven way to reduce stress in the body. Things that happen when you're stressed, like increased heart rate, fast breathing and high blood pressure, all decrease as you relax through deep breathing.


  • Sit or lie flat in a comfortable position

  • Put one hand on your belly just below your ribs and the other hand on your chest

  • Take a deep breath in through your nose, and let your inhale push your hand out. Your chest shouldn't move

  • Breathe out through pursed lips as if you're whistling. Feel the hand on your belly go in, and use it to push all the air out

Do this routine 3 to 10 times. Take your time with each breath. When you're finished, compare how you feel now to when you first started.



What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. You may lose too much body salts and fluids, and get dehydrated. Your healthcare provider should prescribe the medicine loperamide for you during your first 2 months (56 days) of NERLYNX and then as needed. To help prevent or reduce diarrhea:

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs, and H-2 receptor antagonists. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.