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NOW APPROVED for early-stage HER2+ breast cancer

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NERLYNX is the next step in your treatment after trastuzumab-based therapy (eg, Herceptin®) following surgery, and it works to help reduce the risk of your cancer returning. So by committing to NERLYNX, you commit to that next step in treating your HER2+ early-stage breast cancer.

Because NERLYNX is an oral medication taken once a day, you have the freedom to take it from anywhere.

As with any medication, you may experience certain side effects when starting and taking NERLYNX.

Diarrhea is one of the most common and early side effects, and there is medicine available to help with this side effect. It is recommended that you start loperamide (Imodium®) with the first dose of NERLYNX and continue it during the first two months of NERLYNX treatment to help proactively minimize any diarrhea you may experience. Your doctor will tell you the best way to take this medication, as well as other ways to manage diarrhea and other side effects.

WAYS TO MINIMIZE DIARRHEA

The following tips may help you minimize diarrhea, but always talk to your doctor or nurse first before making any changes to your diet.

Foods that are low in fiber

Eg, Bananas, white rice, applesauce, white bread

Visit familydoctor.org and search BRAT diet to learn more

Foods that are high in protein

Eg, Beef, skinless chicken, turkey, eggs

Foods that are high in potassium

Eg, Bananas, skinless potatoes, avocados, asparagus tips

Yogurt

Yogurt contains "good" bacteria known as probiotics, which can shorten the duration of diarrhea

Other dairy products

Eg, Milk, cheese, ice cream

Alcohol, caffeinated drinks, and sugary sodas

Eg, Beer, wine, coffee, soda

Greasy, fatty, and spicy foods

Eg, Fried chicken, pizza, peppers

Foods that are high in fiber

Eg, Popcorn, pickles, whole grain bread, brown rice

Foods that cause intestinal gas

Eg, Broccoli, cabbage, beans, cauliflower

Grapefruit and grapefruit products

Grapefruit

OTHER TIPS TO HELP MINIMIZE DIARRHEA

GETTING HELP

Make sure you work closely with your healthcare team to help minimize diarrhea. Keep a record of how often you experience diarrhea along with any other symptoms. Share this record and talk with your doctor or nurse early and often to better manage your side effects.

Aside from over-the-counter medicines, like loperamide (Imodium), your healthcare team can provide other ways to help you control your diarrhea, including medications and dietary recommendations.

Select IMPORTANT SAFETY INFORMATION

Call your healthcare provider right away if you get any of the following signs or symptoms of liver problems:

  • tiredness

  • nausea

  • vomiting

  • pain in the right upper stomach-area (abdomen)

  • fever

  • rash

  • itching

  • yellowing of your skin or whites of your eyes

Please see additional Important Safety Information below.

how to take NERLYNX

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

NERLYNX (neratinib) may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. You may lose too much body salts and fluids, and get dehydrated. Your healthcare provider should prescribe the medicine loperamide for you during your first 2 months (56 days) of NERLYNX and then as needed. To help prevent or reduce diarrhea:

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

NERLYNX is a prescription medicine used to treat adults who have early-stage breast cancer, which:

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs, and H-2 receptor antagonists. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

Common side effects of NERLYNX include:

These are not all the possible side effects of NERLYNX.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.