“There is tremendous support for you if you need it.”

—Sherry H, treated with NERLYNX

Working with your healthcare team

Side effects can occur with NERLYNX. But there are steps you can take to help manage the side effect of diarrhea and see your treatment through.

Working with your healthcare team from the beginning is the key to success. Here are some simple steps to help prepare you:

Become an advocate in your care

Taking a stand against recurrence starts with education. And it starts here…

  • Questions to ask your doctor about HER2+ breast cancer

    No matter where you are in your treatment-planning process, it is important to partner with your doctor. This downloadable helps you prepare a list of the important questions.

    PDF (English) 
  • Patient brochure

    Your resource to help you get started with NERLYNX and see your treatment through.

    PDF (English) 
    PDF (Español) 
  • Frequently asked questions

    Learn more about NERLYNX and our Puma Patient Lynx™ Support Program.

    Early-stage HER2+ breast cancer FAQs

    PDF (English) 
    PDF (Español) 

    Metastatic breast cancer FAQs

    PDF (English) 
    PDF (Español) 

Puma Patient Lynx™: NERLYNX education and support programs

Puma Patient Lynx™ provides programs and services for support, education, and accessibility. Limitations apply with this program. Puma Biotechnology reserves the right to rescind, revoke, or amend this program without notice. For full terms and conditions, call 1‑855‑816‑5421.

Text Support Program

    When you sign up for this program, you'll receive emails and texts that will help you:

  • Stay committed to taking NERLYNX
  • Remember to take your daily medicine
  • Manage side effects
  • Increase motivation and stay on track
  • Get the most out of your healthcare appointments

To sign up for free,* text LYNX to 82866 or enter your number.

*At no cost with an unlimited texting plan; otherwise, message & data rates may apply. Message frequency determined by user. Text HELP to 82866 for help. Text STOP to 82866 to cancel. Click here for Terms & Conditions.

Mentor Program

If you are considering or already being treated with NERLYNX, our mentor program connects you with someone who currently takes or has taken NERLYNX.

We stand together. Let a mentor's story help you gain confidence in your stand against recurrence with NERLYNX.

    While every experience with NERLYNX is unique, and your doctor should always be your primary source of information for treatment decisions, hearing from someone who has taken NERLYNX helps you:

  • Learn about another person's real-life experiences
  • Understand why they felt NERLYNX was the right step for them
  • Gain confidence to take this next step toward reducing the risk that breast cancer will return
  • Learn about the resources available as you take NERLYNX

The mentor program is here for you with support and resources. Your healthcare team should always be your primary source of information for treatment decisions.

Puma mentors are compensated for their time.

Connect with a mentor

To talk to a mentor, call 1‑855‑816‑5421 or sign up below.

Our support services are designed with you in mind

Currently taking or thinking about taking NERLYNX? Sign up here to receive information and updates.

Would you like to speak with a mentor?
Have one-on-one conversations with women who have experience with NERLYNX.
Are you interested in daily support text messages?
Our FREE§ text message-based program may be helpful to you through treatment with NERLYNX.

§At no cost with an unlimited texting plan; otherwise, message & data rates may apply. Message frequency determined by user. Text HELP to 82866 for help. Text STOP to 82866 to cancel. Click here for Terms & Conditions.

All fields are required. All information collected will be used for sending updates only and will not be shared with third parties other than those contracted with Puma to administer and support the program. By providing your email you are agreeing to receive communications. For more details, see our Privacy Policy.

Puma Patient Lynx™: Support programs to help make NERLYNX accessible

Puma Patient Lynx™ provides programs and services for support, education, and accessibility. Limitations apply with this program. Puma Biotechnology reserves the right to rescind, revoke, or amend this program without notice. For full terms and conditions, call 1‑855‑816‑5421.

NERLYNX Quick Start

Provides a 3-week supply of NERLYNX to eligible patients whose access to medicine is delayed.

    Co-pay Support

  • Commercially insured, eligible patients treated with NERLYNX may pay as little as $10 per prescription||
  • Patients can be enrolled through their specialty pharmacy or clinic

    Patient Assistance Program

  • NERLYNX is provided free to patients who are uninsured and meet certain financial qualifications
  • Information on nonprofit foundations and other potential resources for patients who need financial support

For information or assistance with pharmacy insurance benefits, call 1‑855‑816‑5421.

||Patient must have commercial insurance. Offer is not valid under Medicare, Medicaid, or any other federal or state program.

Antidiarrheal Support Program

Puma offers vouchers that include access to a free supply of certain antidiarrheal medicines. With a prescription, patients can receive up to a 3-month supply of products used for antidiarrheal treatment for free.

You can get a voucher from your healthcare team or the specialty pharmacy that delivers your NERLYNX.

Specialty Pharmacy Services

    Once your doctor prescribes NERLYNX and submits your prescription, you will get a phone call to start the delivery process. The number may be unrecognizable to you, but this call is important to confirm your prescription. These specialty pharmacies help with much more than filling a prescription. They also provide:

  • Understanding of your insurance coverage and help if there are access issues
  • Timely delivery of NERLYNX
  • Nurses and pharmacists who can help with questions about NERLYNX and side effect management

    What is NERLYNX tablets?

  • NERLYNX is a prescription medicine used alone to treat adults with early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer and who have previously been treated

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

    NERLYNX may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. Diarrhea may lead to loss of too much body salts and fluid, which can cause dehydration. Your healthcare provider will prescribe NERLYNX in one of two ways to help manage diarrhea:

IMPORTANT SAFETY INFORMATION

What is the most important information
I should know about NERLYNX (ner links)?

    NERLYNX may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. Diarrhea may lead to loss of too much body salts and fluid, which can cause dehydration. Your healthcare provider will prescribe NERLYNX in one of two ways to help manage diarrhea:

    What is NERLYNX tablets?

  • NERLYNX is a prescription medicine used alone to treat adults with early-stage human epidermal growth factor receptor 2 (HER2)-positive breast cancer and who have previously been treated with trastuzumab-based therapy.
  • NERLYNX is also used with a medicine called capecitabine to treat adults with HER2-positive breast cancer that has spread to other parts of the body (metastatic) and who have received 2 or more anti-HER2 therapy medicines for metastatic breast cancer.

It is not known if NERLYNX is safe and effective in children.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about NERLYNX (ner links)?

NERLYNX may cause serious side effects, including:

  • Diarrhea. Diarrhea is a common side effect of NERLYNX, but it can also be severe. Diarrhea may lead to loss of too much body salts and fluid, which can cause dehydration. Your healthcare provider will prescribe NERLYNX in one of two ways to help manage diarrhea:

      Full dose of NERLYNX:

    • Your healthcare provider will prescribe the antidiarrheal medicine loperamide for you during your first 2 months (56 days) of treatment with NERLYNX and then as needed. Your healthcare provider will tell you exactly how much and how often to take this medicine.
    • If you are prescribed the full dose of NERLYNX from the start of your treatment, be sure that your healthcare provider also prescribes antidiarrheals with NERLYNX. You should start taking loperamide with your first dose of NERLYNX.
    • After 2 months (56 days) of treatment with NERLYNX, follow your healthcare provider’s instructions about taking loperamide as needed to control diarrhea.
      • A lower starting dose of NERLYNX:

      • Your healthcare provider will start you on a lower dose of NERLYNX for the first 2 weeks of treatment and then increase you to a full dose NERLYNX regimen. Tell your healthcare provider right away if you develop diarrhea; you may be prescribed loperamide as needed.

      To help prevent or reduce diarrhea during treatment with NERLYNX:

    • Your healthcare provider may also need to give you additional antidiarrheals, fluids, and electrolytes to manage diarrhea when you start treatment with NERLYNX. Follow your healthcare provider’s instructions on how to take antidiarrheal medicines.
    • Always take antidiarrheals exactly as your healthcare provider tells you.
    • While taking antidiarrheals, you and your healthcare provider should try to keep the number of bowel movements that you have at 1 or 2 bowel movements each day.
    • Tell your healthcare provider if you have more than 2 bowel movements in 1 day, or you have diarrhea that does not go away.
    • Call your healthcare provider right away if you have severe diarrhea or if you have diarrhea along with weakness, dizziness, or fever.

Your healthcare provider may change your dose of NERLYNX, temporarily stop, or completely stop NERLYNX if needed to manage your diarrhea.

See “What are the possible side effects of NERLYNX?” for more information about side effects.

    Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems. You may need a lower dose of NERLYNX.
  • are pregnant or plan to become pregnant. NERLYNX can harm your unborn baby. If you are a female who can become pregnant:
    • Your healthcare provider should do a pregnancy test before you start taking NERLYNX.
    • You should use effective birth control (contraception) during treatment and for at least 1 month after your last dose of NERLYNX.
    • Talk with your healthcare provider about forms of birth control that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant during treatment with NERLYNX.
    • Males with female partners who can become pregnant should use effective birth control during treatment and for 3 months after the last dose of NERLYNX.
  • are breastfeeding or plan to breastfeed. It is not known if NERLYNX passes into your breast milk. Do not breastfeed during treatment and for at least 1 month after your last dose of NERLYNX.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs. You should avoid taking these medicines during treatment with NERLYNX.

What should I avoid while taking NERLYNX?

You should avoid eating products that contain grapefruit during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:

See “What is the most important information I should know about NERLYNX?”

  • Liver problems. Changes in liver function tests are common with NERLYNX. Your healthcare provider should do blood tests before you begin treatment, monthly during the first 3 months, and then every 3 months as needed during treatment with NERLYNX. Your healthcare provider will stop your treatment with NERLYNX if your liver tests show severe problems. Call your healthcare provider right away if you get any of the following signs or symptoms of liver problems:
    • tiredness
    • nausea
    • vomiting
    • pain in the right upper stomach-area (abdomen)
    • fever
    • rash
    • itching
    • yellowing of your skin or whites of your eyes
    The most common side effects of NERLYNX when used alone include:
  • diarrhea
  • nausea
  • stomach-area (abdomen) pain
  • tiredness
  • vomiting
  • rash
  • dry or inflamed mouth, or mouth sores
  • decreased appetite
  • muscle spasms
  • upset stomach
  • nail problems including color change
  • dry skin
  • swelling of your stomach-area
  • nosebleed
  • weight loss
  • urinary tract infection
    The most common side effects of NERLYNX when used with capecitabine include:
  • diarrhea
  • nausea
  • vomiting
  • decreased appetite
  • constipation
  • tiredness/weakness
  • weight loss
  • dizziness
  • back pain
  • joint pain
  • urinary tract infection
  • upper respiratory tract infection
  • swelling of your stomach-area
  • kidney problems
  • muscle spasms

These are not all of the possible side effects of NERLYNX. For more information, ask your Healthcare Provider.

Tell your healthcare provider if you have any side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.

Please see Patient Information.