Not an actual patient.

What is HER2+ breast cancer?

Some people with breast cancer have a gene mutation that causes their cells to make too much of the HER2 (human epidermal growth factor receptor 2) protein. At higher-than-normal levels, HER2 protein promotes the growth of abnormal cells—this causes HER2+ breast cancer. Among people with breast cancer, about 20%—or about 1 in 5—have HER2+ breast cancer.

HER2-cells HER2-cells

HER2+ breast cancer is different from other types of breast cancer, because it:

Until there is a cure for breast cancer, there is still a risk of the cancer progressing.

What is metastatic breast cancer (mBC)?

Metastatic breast cancer—also called Stage IV or advanced breast cancer—is cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body.

In nearly 1 in 4 people (25%) with breast cancer diagnosed at an early stage, the cancer will come back as advanced, or metastatic, breast cancer. In 6 to 10% of new breast cancer cases, the breast cancer is metastatic from the start. This is called de novo metastatic breast cancer.

A person's experience with metastatic breast cancer will depend on how many metastases develop and where they are in the body. Treatment can control metastatic breast cancer for some time, but often the cancer continues to grow or spread.

Getting started with NERLYNX + Capecitabine

NERLYNX is used with a medicine called capecitabine to treat people with HER2+ breast cancer that has spread to other parts of the body. People must have received 2 or more anti-HER2 therapy medicines for metastatic breast cancer to take NERLYNX and capecitabine.

Talk with your doctor about your risk and the role NERLYNX can play in your care.

Learn how NERLYNX may help

Download frequently asked questions

To learn more about NERLYNX for mBC, see a list of commonly asked questions and answers.


What is the most important information I should know about NERLYNX (ner links)?

NERLYNX® (neratinib) may cause serious side effects, including:

Your healthcare provider may change your dose of NERLYNX, temporarily stop or completely stop NERLYNX if needed to manage your diarrhea.

See "What are the possible side effects of NERLYNX?" for more information about side effects.

What is NERLYNX?

It is not known if NERLYNX is safe and effective in children.

Before taking NERLYNX, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to decrease stomach acid, called proton pump inhibitors or PPIs. You should avoid taking these medicines during treatment with NERLYNX.

What are the possible side effects of NERLYNX?

NERLYNX may cause serious side effects, including:
See "What is the most important information I should know about NERLYNX?"

The most common side effects of NERLYNX when used alone include:

The most common side effects of NERLYNX in combination with capecitabine include:

These are not all of the possible side effects of NERLYNX. For more information, ask your Healthcare Provider.

Tell your doctor if you have any side effects that bother you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For Patient Information, please click here.